硕士生导师：微生物学、生物技术与工程
博士生导师：生物与医药
刘爱骅，二级教授、博士生导师、化学生物学与生物传感研究所所长。2004年获日本东北大学药学博士学位，2004—2010年先后在日本产业技术综合研究所、美国密歇根州立大学、俄克拉荷马大学及德克萨斯大学从事研究工作。2010年以中国科学院百人计划引进回国，2010—2016年任中国科学院青岛生物能源与过程研究所研究员、生物传感技术团队负责人。2016年被引进到青岛大学工作。长期从事微生物表面展示、合成生物学、多肽和功能酶，及其在生物传感、大健康与食品安全、体外诊断技术、生物燃料电池等方面的应用研究。 迄今，已在Nature Communications, Journal of the American Chemical Society, Chemical Reviews, Advanced Materials, Journal of Molecular Biology, Bioresource Technology, Analytical Chemistry, Biosensors & Bioelectronics, Antiviral Research 等国际顶级期刊上发表SCI论文120余篇，其中通讯作者或一作论文90多篇，h-index 52。受邀撰写英文合著4部，已在美国出版。授权中国发明专利9项。近年来主持国家重点研发计划重点专项课题、国家自然科学基金重大研究计划培育项目、国家自然科学基金面上项目、中科院知识创新工程重要方向项目等十几项。自2020年以来，连续五年入选“全球前2%顶尖科学家终身科学影响力榜单”（World's Top 2% Scientists, career-long）。
获奖及荣誉:
◆ 入选全球前2%顶尖科学家终身科学影响力榜单(2020—2024)
◆ 山东省优秀研究生导师 （2023）
◆ 中国分析测试协会科学技术奖二等奖（首位）(2019)
◆ 入选中国科学院“百人计划—国外引进杰出人才” (2010)
◆ 美国Sigma Xi科学研究协会杰出会员 (2008)
◆ 日本学术振兴会(JSPS) fellowship (2004)
国际期刊任职:
◆ Frontiers in Chemistry|Analytical Chemistry编辑
◆ Scientific Reports 编委
◆ Frontiers in Bioscience 编委
研究方向:
◆ 微生物表面展示及特异性多肽淘选
◆ 仿生纳米酶
◆ 生物传感及其大健康与食品安全应用
◆ 体外诊断技术
◆ 合成生物学及其生物燃料电池应用
主持国家级、省部级重要科研项目:
8、国家重点研发计划“合成生物学”重点专项课题,“关键酶元件的挖掘改造与电催化机制解析”（2021YFA09104001），项目起止年月：2021年12月至2026年11月。
7、国家自然科学基金面上项目，“新冠病毒刺突蛋白受体结合域的靶向多肽筛选及其检测应用”（22174081），项目起止年月：2022年1月至2025年12月。
6、国家自然科学基金面上项目，“靶向磁性纳米仿酶多功能探针的构建及其食源性致病菌检测新方法研究”（81673172），项目起止年月：2017年1月至2020年12月。
5、国家自然科学基金面上项目，“抗逆性好、特异、高效价抗体替代物的筛选及其在新型无标记肿瘤标志物电化学阻抗免疫传感器中的应用研究”（21475144），项目起止年月：2015年1月至2018年12月。
4、国家自然科学基金重大研究计划培育项目，“金纳米结构/特异性配体自组装病毒样聚集体的构筑、表面等离子共振光谱及其肿瘤靶向、光热疗法原理研究”（91227116），项目起止年月：2013年1月至2015年12月。
3、国家自然科学基金面上项目，“基于酵母表面酶共展示全细胞的新型电化学顺序酶生物传感器的构筑研究”（21275152），项目起止年月：2013年1月至2016年12月。
2、山东省自然科学基金重大基础研究项目,“前列腺特异抗原的抗体类似物的规模化制备及检测试剂盒研发”（ZR2018ZC0125）,项目起止年月：2018年6月—2020年12月。
1、中国科学院知识创新工程重要方向性项目，“基于丝状病毒和纳米技术的新型蛋白质芯片”（KSCX2-YW-BR-7），项目起止年月：2010年5月至2015年4月。
代表性Top一区SCI论文（*通讯作者）:
32. Bo Liang, Jing Yang, Chenfei Meng, Yaru Zhang, Lu Wang, Li Zhang, Jia Liu, Zhenchao Li, Serge Cosnier*, Aihua Liu*, Jianming Yang*, Efficient conversion of hemicellulose into high-value product and electric power by enzyme-engineered bacterial consortia, Nature Communications 2024, 15, 8764.
31. Tao Dong, Guangze Sun, Aihua Liu*, Universal All-In-One Lateral Flow Immunoassay with Triple Signal Amplification for Ultrasensitive and Simple Self-Testing of Treponema pallidum Antibodies, Analytical Chemistry 2024, 96, 17537-17545 （封面文章）
30. Shuang Pang, Mingyang Wang, Jinlong Yuan, Zhonghuang Yang, Haipeng Yu, Haohan Zhang, Tao Dong, and Aihua Liu*, Sensitive Dual-Signal ELISA Based on Specific Phage-Displayed Double Peptide Probes with Internal Filtering Effect to Assay Monkeypox Virus Antigen, Analytical Chemistry 2024, 96, 24, 10064-10073.
29. Yaru Zhang, Zhenchao Li, Xin Zhang, Mingyang Wang, Ziting Lin, Ying Zhang, and Aihua Liu*, MnO2nanosheets based catechol oxidase mimics for robust electrochemical sensor: Synthesis, mechanism and its application for ultrasensitive and selective detection of dopamine, Chemical Engineering Journal 2024, 493, 152656.
28. Mingyang Wang, Shuang Pang, Haohan Zhang, Zhonghuang Yang, Aihua Liu*, Phage display based biosensing: Recent advances and challenges,Trends in Analytical Chemistry 2024, 173, 117629.
27. Ziting Lin, Tao Dong, Lingxi Niu, Xin Zhang, Mingyang Wang, Xuan Liu, Yuanyuan Ca, and Aihua Liu*, Mechanism of ferrous ions reversibly inhibiting of oxidase-Like activity of Co3O4 nanowires and its application in horticultural fertilizer analysis, Chemical Engineering Journal 2024, 482,148775.
26. Tao Dong, Mingyang Wang, Junchong Liu, Pengxin Ma, Shuang Pang, Wanjian Liu and Aihua Liu*, Diagnostics and Analysis of SARS-CoV-2: Current Status, Recent Advances, Challenges and Perspectives, Chemical Science 2023,14, 6149–6206.
25. Tao Dong, Xin Zhang, Jinlong Yuan, Ziting Lin, Pengxue Yin, Haipeng Yu, Mingyang Wang, and Aihua Liu*, Sensitive lateral flow immunoassay based on specific peptide and superior oxidase mimics with a universal dual-mode significant signal amplification, Analytical Chemistry 2023, 95, 12532–12540.
24. Junchong Liu, Shuang Pang, Mingyang Wang, Haipeng Yu, Pengxin Ma, Tao Dong, Zongmei Zheng, Yiming Jiao, Yaru Zhang, and Aihua Liu*, An ultrasensitive ELISA to assay femtomolar level SARS-CoV-2 antigen based on specific peptide and tyramine signal amplification, Sensors and Actuators B: Chemical 2023, 387, 133746.
23. Jialin Sai, Lu Zhou, Lin Jiang, Dongguo Xue, Renjun Pei, Aihua Liu*, and Lijun Xu*, Dual Signal Amplification by Urease Catalysis and Silver Nanoparticles for Ultrasensitive Colorimetric Detection of Nucleic Acids, Analytical Chemistry 2023, 95, 11359–11364.
22. Yuanyuan Cai, Tao Dong, Xin Zhang, andAihua Liu*, Morphology and Enzyme-Mimicking Activity of Copper Nanoassemblies Regulated by Peptide: Mechanism, Ultrasensitive Assaying of Trypsin, and Screening of Trypsin Inhibitors, Analytical Chemistry 2022, 94,18099–18106.
21. Junchong Liu, Pengxin Ma, Haipeng Yu, Mingyang Wang, Pengxue Yin, Shuang Pang, Yiming Jiao, Tao Dong, and Aihua Liu*,Discovery of a Phage Peptide Specifically Binding to the SARS-CoV-2 Spike S1 Protein for the Sensitive Phage-Based Enzyme-Linked Chemiluminescence Immunoassay of the SARS-CoV-2 Antigen, Analytical Chemistry 2022, 94, 11591–11599.
20. Lingxi Niu, Yuanyuan Cai,Tao Dong, Yujiao Zhang, Xuxin Liu, Xin Zhang, Lingxing Zeng*, Aihua Liu*, Vanadium nitride@carbon nanofiber composite: Synthesis, cascade enzyme mimics and its sensitive and selective colorimetric sensing of superoxide anion, Biosensors and Bioelectronics 2022, 210, 114285.
19. Yanbo Wang, Mingyang Wang, Haipeng Yu, Ge Wang, Pengxin Ma, Shuang Pang, Yiming Jiao,Aihua Liu*, Screening of peptide selectively recognizing prostate-specific antigen and its application in detecting total prostate-specific antigen, Sensors and Actuators B: Chemical 2022,367,132009.
18. Yuanyuan Cai, Mingyang Wang, Xinxin Xiao, Bo Liang, Shuqin Fan, Zongmei Zheng, Serge Cosnier, Aihua Liu*, A membraneless starch/O2 biofuel cell based on bacterial surface regulable displayed sequential enzymes of glucoamylase and glucose dehydrogenase,Biosensors and Bioelectronics 2022, 207,114197.
17. Ge Wang, Pengxue Yin, Jin Wang, Pengxin Ma, Yanbo Wang, Yuanyuan Cai, Huan Qi*, Aihua Liu*, Specific heptapeptide screened from pIII phage display library for sensitive enzyme-linked chemiluminescence immunoassay of vascular endothelial growth factor, Sensors & Actuators: B. Chemical 2021,333, 129555.
16. Shuqin Fan, Bo Liang, Xinxin Xiao, Lu Bai, Xiangjiang Tang, Elisabeth Lojou*, Serge Cosnier*, and Aihua Liu*, Controllable Display of Sequential Enzymes on Yeast Surface with Enhanced Biocatalytic Activity toward Efficient Enzymatic Biofuel Cells, Journal of American Chemical Society 2020,142, 3222−3230.
15. Xinxin Xiao, Hong-qi Xia, Ranran Wu, Lu Bai, Lu Yan, Edmond Magner, Serge Cosnier, Elisabeth Lojou*, Zhiguang Zhu*, and Aihua Liu*, Tackling the Challenges of Enzymatic (Bio)fuel Cells,Chemical Reviews 2019,119, 9509−9558.
14. Xuan Liu, Lu Yan, Han Ren, Yuanyuan Cai, Chongyang Liu, Lingxing Zeng, Jing Guo*, and Aihua Liu*, Facile synthesis of magnetic hierarchical flower-like Co3O4spheres: Mechanism, excellent tetra-enzyme mimics and their colorimetric biosensing applications, Biosensors & Bioelectronics 2020,165,112342.
13. Lei Han, Hongqi Xia, Long Yin, Valery A. Petrenko, and Aihua Liu*, Selected landscape phage probe as selective recognition interface for sensitive total prostate-specific antigen immunosensor, Biosensors & Bioelectronics 2018,106, 1−6.
12. Aihua Liu*, Qiaolin Lang, Bo Liang, and Jianguo Shi, Sensitive detection of maltose and glucose based on dual enzyme-displayed bacteria electrochemical biosensor, Biosensors & Bioelectronics 2017,87, 25–30.
11. Chuantao Hou, Shuqin Fan, Qiaolin Lang, andAihua Liu*, Biofuel cell based self-powered sensing platform for L-cysteine detection, Analytical Chemistry 2015, 87, 3382−3387.
10. Shuqin Fan, Chuantao Hou, Bo Liang, Ruirui Feng, and Aihua Liu*, Microbial surface displayed enzymes based biofuel cell utilizing degradation products of lignocellulosic biomass for direct electrical energy, Bioresource Technology 2015,192,821–825.
9. Huan Qi, Fei Wang, Valery A. Petrenko, and Aihua Liu*, Peptide microarray with ligands at high density based on symmetrical carrier landscape phage for detection of cellulase, Analytical Chemistry 2014,86,5844–5850.
8.Qiaolin Lang, Fei Wang, Long Yin, Mingjun Liu, Valery A. Petrenko, and Aihua Liu*, Specific probe selection from landscape phage display library and its application in enzyme-linked immunosorbent assay of free prostate-specific antigen, Analytical Chemistry 2014,86, 2767–2774.
7. Xiangjiang Tang, Tingting Zhang, Bo Liang, Dongfei Han, Lingxing Zeng, Cheng Zheng, Tie Li, Mingdeng Wei, and Aihua Liu*, Sensitive electrochemical microbial biosensor forp-nitrophenylorganophosphates based on electrode modified with cell surface-displayed organophosphorus hydrolase and ordered mesopore carbons, Biosensors & Bioelectronics 2014,60, 137–142.
6. Bo Liang, Qiaolin Lang, Xiangjiang Tang, andAihua Liu*, Simultaneously improving stability and specificity of cell surface displayed glucose dehydrogenase mutants to construct whole-cell biocatalyst for glucose biosensor application, Bioresource Technology 2013,147, 492–498.
5. Bo Liang, Liang Li, Xiangjiang Tang, Qiaolin Lang, Hongwei Wang, Feng Li, Jianguo Shi, Wei Shen, Ilaria Palchetti, Marco Mascini, and Aihua Liu*, Microbial surface display of glucose dehydrogenase for amperometric D-glucose biosensor,B iosensors & Bioelectronics 2013,45, 19–24.
4. Lin Xia, Bo Liang, Liang Li, Xiangjiang Tang, Ilaria Palchetti, Marco Mascini,and Aihua Liu*, Direct energy conversion from xylose using xylose dehydrogenase surface displayed bacteria based enzymatic biofuel cell, Biosensors & Bioelectronics 2013,44, 160–163.
3. Aihua Liu, Gopal Abbineni, and Chuanbin Mao*, Nanocomposite films layer-by-layer assembled from genetically engineered filamentous viruses and gold nanoparticles: nanoarchitecture- and humidity-tunable surface plasmon resonance spectra, Advanced Materials 2009,21,1001–1005.
2. Aihua Liu, Mingdeng Wei, Itaru Honma, and Haoshen Zhou*, Biosensing properties of titanate-nanotube film: selective detection of dopamine in the presence of ascorbate and uric acid, Advanced Functional Materials 2006,16, 371–376.
1. Aihua Liu and Jun-ichi Anzai*, Use of polymeric indicator for electrochemical DNA sensor: poly(4-vinylpyridine) derivative bearing [Os(5,6 dimethyl-1,10-phenanthroline)2Cl]2+, Analytical Chemistry 2004,76, 2975–2980.
授权专利:
9. 刘爱骅、张玉娇，一种基于仿NADH氧化酶和生物酶的级联反应比色检测NADH的方法，专利号：ZL202110081928.7，授权公布日：2022-07-29
8. 刘爱骅、王戈，一种短肽、检测试剂盒及检测血管内皮生长因子的方法,专利号：ZL202010304369.7，授权公布日：2022-03-15
7. 刘爱骅，一种利用细胞表面可控展示顺序酶构建的传感器检测糖的方法，专利号：ZL201710903067X，授权公布日：2020-05-08
6. 刘爱骅、祁环，一种多肽及其应用和将多肽共价连接到固相界面的方法，中国专利号：ZL201410038545.1, 授权公布日：2017-12-19
5. 刘爱骅、刘培，一种检测病原微生物的方法，中国专利号：ZL201710036540.9, 授权公布日：2018-07-20
4. 刘爱骅、侯传涛，一种生物质能源转化和贮存的集成器件及其制备方法，中国专利号：ZL201610913103.6, 授权公布日：2018-09-28
3. 刘爱骅、侯传涛，一种定量检测L-半胱氨酸的方法，中国专利号: ZL201410714016.X, 授权公布日：2018-06-08
2. 刘爱骅、梁波，一种基于冰核蛋白的木糖脱氢酶细菌表面展示系统及其应用，中国专利号：ZL201210007398.2, 授权公布日：2015-04-22
1. 刘爱骅、祁环、梁波、白罚利，一种从里氏木霉中分离多糖水解酶的方法，中国专利号：ZL201210052751.9, 授权公布日：2015-03-04
欢迎具有生物学、生物医学、化学生物学、药学、分析化学等相关背景的学生报考（包括调剂）。本研究所长期诚聘优秀博士和博士后。欢迎加盟！
联系方式： E-mail: liuah@qdu.edu.cn
