沙珍霞，女，博士，青岛大学生命科学学院教授、二层次特聘教授，博士生导师，水生生物学科负责人，青岛大学水生生物技术研究院执行院长，兼任中国水产学会成立水产生物技术与遗传育种专业委员会副主任委员，中国科协人才评审专家，青岛市营养学会理事等。主要从事水产生物技术和遗传育种、水生生物资源开发利用研究。主持863项目、国家重点研发课题、2030重大育种专项子课题、国家自然科学基金面上项目等国家级课题12项，并主持省市及横向课题多项；发表研究论文100余篇，授权国家发明专利10余项；获得省部级及水科院科技成果奖励等10余项；获中国水产科学研究院首届中青年拔尖人才、青岛市第六届青年科技奖、青岛大学最美教师等荣誉称号。
研究方向：
水生生物技术与生物资源利用；海洋鱼类细胞生物学及免疫学
联系方式：
TEL：0532-85959690
E-mail: shazhenxia@163.com
近五年主持科研项目情况:
1. 国家重点研发计划课题，鲆鲽类主要经济性状形成的遗传基础与调控机制（2022YFD2400401），2022-2026
2. 科技创新2030-农业生物育种重大项目子课题，集约高产鱼新品种设计与培育-课题1- 高产性状重驯化基因组设计与新种质创新（2023ZD0405501），2023-2025
3. 国家自然科学基金面上项目，浒苔绿潮衰亡腐烂对近海底栖经济鱼类褐牙鲆的影响机理研究（42276218），2023-2026
4. 国家自然科学基金面上项目，C5aR1介导的C5a/C5aR1补体通路对鱼类细菌性炎症的作用及调控机理研究-以半滑舌鳎为例（41976102），2020-2023
5. 国家自然科学基金面上项目，半滑舌鳎补体信号通路及抗菌免疫防御机理（31572644），2016-2019
6. 国家重点研发计划子课题，重要水产养殖生物抗病和抗逆性状的遗传基础与调控机制-课题1-海水鱼类抗病与抗逆性状形成的分子机理（2018YFD0900301-3），2018-2022
7. 山东省院士专项子课题，半滑舌鳎抗病性状解析，2023-2026
8. 山东省重点研发计划子课题，水产种质资源挖掘与精准鉴定子课题（2021LZGC028），2021-2025
近三年发表文章：
1. Chang MY, Shi KP, Xia JQ, Zhang RX, Li YS, Zang SQ, Tan SX, Wang WW, Chen SL, Sha, ZX(通讯作者). 2025. Genome-wide association study and transcriptome analysis provide the SNPs and molecular insights into the visceral nodular disease tolerance in half-smooth tongue sole (Cynoglossus semilaevis). Aquaculture, 595, 741585.
2. Zhou FF, Chang MY, Ruan SJ, Huang WQ, Sha ZX(共同通讯), Cai BX, Liu Z. 2024. Transcriptomic and histologic analyses preliminarily reveal the immune-metabolic response mechanism to saline-alkaline in large yellow croaker (Larimichthys crocea). Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 52, 101282.
3. Zhou FF, Chang MY, Lan Y, Huang WQ, Sha ZX(共同通讯), Liu JF, Zhang ZP, Ruan SZ, Liu Z. 2024. Effects of saline-alkaline stress on metabolomics profiles, biochemical parameters, and liver histopathology in large yellow croaker (Larimichthys crocea). Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 52, 101343.
4. Ma J., Shi KP, Zhang WJ, Han S, Wu ZD, Wang MY, Zhang HB, Sun JC, Wang NN, Chang MY, and Shi XY, Tan SX, Wang WW, Zang SQ, Sha ZX(通讯作者). 2024. The survival, gene expression, and DNA methylation of Paralichthys olivaceus impacted by the decay of green tide and bacterial infection in both laboratory and field simulation experiments. Science of The Total Environment, 942, 173427.
5. Wu ZD, Zang SQ, Wang WW, Tan SX, Xu Q, Chen XJ, Han S, Ma J, Shi KP, Wang NN, Cheng JY, Sha ZX(通讯作者). 2024. Manipulated C5aR1 over/down-expression associates with IL-6 expression during bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis). Fish & Shellfish Immunology, 151:109706.
6. Wang WW, Wei S, Chen YD, Tan SX, Shi KP, Zang SQ, Wang MM, Yang T, Yang YM, Cui ZK, Sha ZX(通讯作者). 2024. The ceRNA network indicates its immune function in peripheral blood leukocytes of half-smooth tongue sole (Cynoglossus semilaevis) after stimulation with chitosan oligosaccharide. Journal of Ocean University.
7. Han S, Tan SX, Liu HN, Wang NN, Liu XB, Li ZJ, Wu ZD, Ma J, Wang WW, Shi KP, Sha ZX(通讯作者). 2023. Analysis of alternative splicing provides insights into its vital roles in immune responses of half-smooth tongue sole (Cynoglossus semilaevis) against Vibrio anguillarum. Aquaculture. Dec 27:740526.
8. Liu HN, Tan SX, Chen YD, Chen XJ, Liu XB, Li ZJ, Wang NN, Han S, Wu ZD, Ma J, Shi KP, Wang WW, Sha ZX(通讯作者). 2023. Regulatory mechanism of miR-722 on C5aR1 and its functions against bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis). Journal of Biological Macromolecules.252:126445.
9. Liu HN, Tan SX, Han S, Liu XB, Li ZJ, Wang NN, Wu ZD, Ma J, Shi KP, Wang WW, Sha ZX(通讯作者). 2024. Effects of miR-722 on gene expression and alternative splicing in the liver of half-smooth tongue sole after infection with Vibrio anguillarum. Fish & Shellfish Immunology. 144:109275.
10. Wang WW, Xu Q, Zang SQ, Liu XB, Liu HN, Li ZJ, Fan QX, Tan SX, Shi KP, Xia YT, Sha ZX(通讯作者). 2023. Inflammatory reaction and immune response of half-smooth tongue sole (Cynoglossus semilaevis) after infection with Vibrio anguillarum. Fish & Shellfish Immunology. 141:109043.
11. Shi KP, Fan QX, Zhan M, Pang M, Tan SX, Wang WW, Wang MY, Sha ZX(通讯作者). 2023. Exploring the effect of Ulva prolifera decay on the immune tissue of Paralichthys olivaceus based on transcriptomics and histopathological analysis. Marine pollution Bulletin. 194(Pt A):115410.
12. Zhan M, Shi KP, Zhang X, Fan QX, Xu Q, Liu XB, Li ZJ, Liu HN, Xia YT, Sha ZX(通讯作者). 2023. Histological assessment and transcriptome analysis provide insights into the toxic effects of perfluorooctanoic acid to juvenile half smooth tongue sole Cynoglossus semilaevis. Journal of Ocean University of China. 22(6):1635-48.
13. Xia YT, Zhong XY, Zhang XX, Zhang XJ, Yuan JB, Liu CZ, Sha ZX(共同通讯). 2023. Li FH. Gene Structure, Expression and Function Analysis of MEF2 in the Pacific White Shrimp Litopenaeus vannamei. International Journal of Molecular Sciences. 2023 Mar 18;24(6):5832.
14. Liu XB, Wang WW, Tan SX, Liu HN, Li ZJ, Wang NN, Ma J, Han S, Wu ZD, Shi KP, Sha ZX(通讯作者). 2023. C5a drives the inflammatory response with bacterial dose effect by binding to C5aR1 in zebrafish infected with Aeromonas hydrophila. Fish & Shellfish Immunology. 139,108873.
15. Li ZJ, Tan SX, Qi LJ, Chen YD, Liu HN, Liu XB, Sha ZX(通讯作者). 2023. Genome-wide characterization of integrin (ITG) gene family and their expression profiling in half-smooth tongue sole (Cynoglossus semilaevis) upon Vibrio anguillarum infection. Comparative Biochemistry and Physiology-Part D: Genomics and Proteomics. 47,101099.
16. Fan QX, Shi KP, Zhan M, Xu Q, Liu XB, Li ZJ, Liu HN, Xia YT, Chen YD, Shi XY, Sha ZX(通讯作者). 2022.Acute damage from the degradation of Ulva prolifera on the environmental microbiota, intestinal microbiota and transcriptome of Japanese flounder Paralichthys olivaceus. Environmental Pollution. 302,119022.
17. Ma H, Chen YD, Yu MJ, Chen XJ, Qi LJ, Wei S, Fan QX, Xu Q, Zhan M, Sha ZX(通讯作者). 2021. Immune role of the complement component 6 gene and its associated novel miRNA, miR-727, in half-smooth tongue sole (Cynoglossus semilaevis). Developmental and comparative immunology. 123,104156.
18. Wei S, Chen YD, Huang L, Ma H, Qi LJ, Wang Q, Sun MJ, Zhang X, Sha ZX(通讯作者). 2021. Analysis of lncRNA and mRNA expression profiles in peripheral blood leukocytes of the half-smooth tongue sole (Cynoglossus semilaevis) treated with chitosan oligosaccharide. Developmental & Comparative Immunology, 120:104043.
19. An ML, Qu CF, Miao JL, Sha ZX(通讯作者). 2021. A Class II CPD Photolyase and a 6-4 Photolyase with Photorepair Activity from the Antarctic Moss Pohlia nutans M211. Photochemistry and Photobiology, 97(6):1527-1533.
20. Qi LJ, Chen Yd, Shi KP, Ma H, Wei S, Sha ZX(通讯作者). 2021. Combining of transcriptomic and proteomic data to mine immune-related genes and proteins in the liver of Cynoglossus semilaevis challenged with Vibrio anguillarum. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 39,100864.
21. An ML, Qu CF, Miao JL, Sha ZX(共同通讯). 2021. Two class II CPD photolyases, PiPhr1 and PiPhr2, with CPD repair activity from the Antarctic diatom Phaeodactylum tricornutum ICE-H. 3 Biotech, 11(8):1-9.
近三年授权的国家发明专利:
1. 沙珍霞，刘红宁，陈亚东，王宁宁，刘鑫宝，谭苏旭，史鲲鹏，韩森，陈学杰。一种miRNA及其在调控C5aR1基因中的应用，ZL202211414910.5，授权公告日：2024.04.09.
2. 沙珍霞，陈亚东，孙璐明，汪林庆，陈松林。一种用于鱼类单核/吞噬细胞分离、培养及功能验证方法，ZL201610775091.5，授权公告日：2023.10.31.
3. 沙珍霞，王文文，李竹君，刘鑫宝，刘红宁，韩森，武振东，马洁，谭苏旭。半滑舌鳎抗病基因PPARα及其编码蛋白的应用，ZL 202310720402.8，授权公告日：2023.08.29.
